Lizzo on Sunday won the Grammy for Record of the Year – the award honouring overall performance of a song – for her single "About Damn Time," besting a crowded field, including Beyonce and Adele.

Scoring the prize is something of a comeback for Lizzo, who was widely tipped to be the big winner in 2020 but lost all her chances at a major award to pop phenom Billie Eilish.

She dedicated the prize to the late pop icon Prince, her lifelong hero with whom she also worked.

"We are good inherently," she said through tears in a speech that brought the audience to its feet. "And anybody at home who feels misunderstood or on the outside looking in, like I did, just stay true to yourself."

"I promise you, you will find people, you will attract people in your life who believe in you and support you."

Lizzo soared into the global consciousness in 2019, seducing legions of fervent fans with her soulful self-love anthems, zesty raps and even the occasional twerk.

The 31-year-old artist born Melissa Viviane Jefferson debuted in 2013 but did not achieve mainstream success until the release of her third studio album "Cuz I Love You".

The hitmaker returned last year with a new 12-track record "Special", and will embark on a global tour this month.

Meanwhile, Harry Styles won the coveted Grammy for Album of the Year.

The pop sensation scored the award for his third album "Harry's House", his most intimate yet, which combined twangy synths and soft acoustics with very personal lyrics."

This doesn't happen to people like me very often, and this is so nice," he said onstage.

The American blues, folk and country singer Bonnie Raitt scored an unexpected Grammy for Song of the Year, an honour for her track "Just Like That." (AFP)