Antonio Conte has left Tottenham "by mutual agreement" after 16 months in charge, the Premier League club announced on Sunday.

His departure comes after the Italian's extraordinary post-match rant following a 3-3 draw at Southampton on March 18, a match in which they blew a 3-1 lead.

The 53-year-old, who took over in November 2021, will be replaced by his assistant Cristian Stellini until the end of the season.

"We can announce that head coach Antonio Conte has left the club by mutual agreement," a club statement read.

"We achieved Champions League qualification in Antonio's first season at the club. We thank Antonio for his contribution and wish him well for the future.

"Cristian Stellini will take the team as acting head coach for the remainder of the season, along with Ryan Mason as assistant head coach."

Spurs chairman Daniel Levy added: "We have 10 Premier League games remaining and we have a fight on our hands for a Champions League place.

"We all need to pull together. Everyone has to step up to ensure the highest possible finish for our club and amazing, loyal supporters."

Conte leaves with Spurs fourth in the Premier League, but only two points above fifth-placed Newcastle, who have two games in hand on the London side in the race for Champions League qualification.

Stellini previously stood in for Conte on the touchline this season when the Italian was recovering from gallbladder surgery.

Conte won league titles in his previous three spells in club management at Juventus, Chelsea and Inter Milan, but was unable to end Tottenham's 15-year wait to win a major trophy.

His contract was due to expire at the end of the season.

Conte labelled his players "selfish" and accused them of not being able to perform under pressure in the tirade after the draw against Southampton.

He also took aim at Tottenham's long trophy drought and pinned the blame on a culture of repeatedly changing managers. (AFP)