Locals and tourists fled hotspots on the Greek island of Rhodes on Sunday, as firefighters, backed by water jets and helicopters, battled a blaze that sparked the country's largest-ever fire evacuation.

Wind gusts of up to 49 kilometres per hour were complicating efforts to bring the flames under control.

The island of Rhodes is one of Greece's most popular tourist destinations, particularly with British, German and French tourists – many of whom were being rapidly moved out of the path of the flames.

As Greece has been battered by an extended spell of extreme heat, flames have burned for nearly a week on the island. Temperatures, which reached 45 degrees Celsius (113 degrees Fahrenheit) in central Greece on Sunday, were expected to dip on Monday before the mercury rises again for another four-day heatwave.

"This is the biggest fire evacuation ever in Greece," said Konstantia Dimoglidou, a Greek police spokeswoman.

"We had to evacuate an area of 30,000 people."

Police said that authorities had transported some 16,000 people across land, with 3,000 evacuated by sea, and others fleeing by road or under their own transport after being told to leave the area.

German travel giant Tui said it was suspending all of its inbound passenger flights to Rhodes until Tuesday but would fly in empty planes to help evacuate tourists.

The low-cost British carrier Jet2 also said it had cancelled "all flights and holidays" to the island.

Authorities have warned that the battle to contain the flames – raging in the middle of peak tourism season – will take several days.

More than 260 firefighters, backed by 18 aircraft, were battling the fire on Sunday, with Croatia, France, Slovakia and Turkey having contributed equipment and personnel, officials said. (AFP)