The Amazon rainforest is facing a barrage of pressures that might tip it into large-scale ecosystem collapse as soon as 2050, according to new research published on Wednesday warning of dire consequences for the region and the world.

The Amazon, which holds more than 10 percent of the world's biodiversity, helps stabilise the global climate by storing the equivalent of around two decades of emissions of planet-warming carbon dioxide.

But stress from deforestation, drought, fire and rising temperatures have eroded the ability of the Amazon's forests to withstand shocks, with scientists warning this could trigger a so-called "tipping point", pitching the crucial ecosystem into irreversible transition in the coming decades.

In the latest study, published in the journal Nature, an international group of scientists estimated that between 10 and 47 percent of the Amazon will be exposed to stress by 2050 that could lead to widespread ecosystem change.

That could cause the critical ecosystem to stop absorbing or even to release the carbon it stores, further driving global warming and intensifying its effects.

"We are approaching a potential large-scale tipping point, and we may be closer (both at local scales and across the whole system) than we previously thought," said lead author Bernardo Flores, of the Federal University of Santa Catarina, in Florianopolis, Brazil.

The researchers used information from computer models, observations and evidence of past changes going back thousands of years to map out the complexity of the forest systems and identify key causes of stress.

They then analysed these stressors -- including global warming, annual rainfall, the length of the dry season and deforestation -- to see how these might act individually or together to cause feedback loops that could trigger a major collapse.

By 2050 the Amazon could be exposed to unprecedented levels of water stress, they said.

Previous research has suggested that global heating -- which has on average warmed Earth's surface around 1.2C above preindustrial levels -- could by itself push the Amazon into a far drier savannah-like state.

The latest study suggested its fate could be more complex than that.

While some areas could transition into "white-sand savannas", which are already expanding in the Amazon after wildfires, other areas of the Amazon could see patchy coverage of fire-tolerant trees interspersed with invasive grasses.

Wetter areas could remain as degraded forest, with fewer tree species and a greater proportion of fast-growing plants like bamboo.

"We have evidence showing that rising temperatures, extreme droughts and fires can affect how the forest functions and change which tree species can integrate the forest system," said co-author Adriane Esquivel-Muelbert from Britain's Birmingham Institute of Forest Research.

Swathes of the Amazon region were gripped by a brutal drought in recent months that shrivelled key waterways, withered crops and stoked wildfires.

Scientists from the World Weather Attribution group have said the historic dry spell was driven chiefly by climate change, more than the naturally occurring El Nino weather phenomenon.

Flores said the severe drought foreshadows the climatic conditions expected for the region in the early 2030s. (AFP)