Gaza's civil defence agency said on Saturday an Israeli air strike on a school housing displaced Palestinians killed 93 people, as Israel's military accused militants of using the building as a command centre.

Hamas denounced the "dangerous escalation" in north Gaza, which came after international mediators invited the warring sides to resume next Thursday talks towards a long-sought ceasefire and hostage-release deal.

Jordan's foreign ministry said the timing of the school strike "is an indication of the Israeli government's efforts to obstruct and thwart these efforts".

Civil defence in the Hamas-ruled territory said three Israeli missiles hit the school in Gaza City while people performed dawn prayers.

"Their bodies were torn apart," civil defence spokesman Mahmud Bassal said. "It reminds us of the first days of the war in the Gaza Strip."

With most of Gaza's 2.4 million people displaced during the war started by Hamas's October 7 attack on southern Israel, many have sought refuge in school buildings, which have been hit at least 14 times since July 6.

Israel's army said on Saturday it had "precisely struck Hamas terrorists operating within a Hamas command and control centre embedded in the Al-Tabieen school".

The military has repeatedly made similar accusations after strikes on the school shelters. Hamas has previously denied Israeli claims that it uses schools, hospitals and other civilian facilities for military aims. (AFP)