The Hang Seng Index fell 182.41 points, or 1.05 percent, to open at 17,261.89 on Monday.
Uncertainty over the US economy's health is rippling through markets, adding fuel to an already-volatile period that has investors grappling with a shift in Federal Reserve policy, a tight US election and worries over stretched valuations.
US stocks tumbled on Friday after closely watched jobs data showed labour market momentum slowing more than expected, suggesting a narrower path for the US to achieve a soft landing, in which the Fed is able to cool inflation without badly damaging economic growth.
The Fed is expected to cut interest rates at its September meeting, but the data revived fears that months of elevated borrowing costs have already started to pressure the economy. (with additional reporting from Xinhua and Reuters)