The Hang Seng Index fell 98.43 points, or 0.45 percent, to open at 22,015.08 points on Friday.

Overnight the main Wall Street indices closed between 0.1 percent and 0.4 percent lower on concerns about an escalation in the Israel-Iran conflict, with oil prices spiking.

Markets are looking ahead to Friday's September jobs report, which will influence upcoming Federal Reserve decisions on whether to keep cutting interest rates. (with additional reporting by Xinhua and AFP)