The Hang Seng Index lost 262.24 points, or 1.1 percent, to open at 23,643.32 on Tuesday.
Investor sentiment has been jolted in recent weeks by fears that the US President Donald Trump's hardball policies could deal a painful blow to the global economy.
April 2 is now the focus of attention, with Trump labelling it "Liberation Day" as he prepares to unveil a raft of "reciprocal" measures -- imposing tariffs on other countries equal to those in place against the United States. (with additional reporting from Xinhua and AFP)