Chief Secretary Eric Chan said Washington's move to impose tariffs on imports from around the world does not conform to international practice.
In an interview with Sing Tao Daily published on Monday, Chan said that by imposing "very high" tariffs, the United States wanted other countries to act according to its wishes and neglected international norms and free trade.
He also denounced the United States for imposing sanctions on mainland and Hong Kong officials, saying they represented interference in the nation's internal affairs.
Chan noted that threats to national security still exist as interference in the SAR's national security trials show.
The public has to develop an awareness of the need to safeguard national security, he said.
Chan also told local newspaper Ta Kung Pao that national security does not just include military security, pointing to the threat of financial systemic risks posed by the so-called "reciprocal tariffs" imposed by the United States.
He said recent US adjustments to the levies are not simply an economic measure but carry a political motive.
The senior official said the US tariffs have seriously affected Hong Kong's business environment and financial security.
Chan emphasised that in the face of unreasonable suppression from external forces, the public has to be more united and safeguard the nation's sovereignty, security and development interests.
On the eve of the 10th National Security Education Day, he said an opening ceremony and thematic seminar will be held on Tuesday and that a thematic exhibition to mark the fifth anniversary of the implementation of the national security law will be held this quarter.