The Hang Seng Index lost 42 points, or 0.19 percent, to open at 22,030 on Thursday.
Mainland stocks opened lower, with the benchmark Shanghai Composite Index down 0.04 percent to open at 3,295.
The Shenzhen Component Index opened 0.02 percent lower at 9,933.
The ChiNext Index, tracking China's Nasdaq-style board of growth enterprises, was down 0.15 percent to open at 1,946.
The ChiNext Index, together with the Shenzhen Component Index and other indices, reflects the performance of stocks listed on the Shenzhen Stock Exchange. (Xinhua)