Cathay Pacific on Wednesday said it does not operate passenger flights over Pakistani airspace, while cargo flights have averted the region since the end of April.

The airline's statement came amid the worst violence between India and Pakistan in two decades, after New Delhi launched missile strikes on Pakistan and Pakistani-controlled Kashmir.

Hong Kong's flagship carrier said it "proactively reviews areas of concern" to ensure its flight routings remain safe, and all decisions are made with the safety of passengers and crew in mind.

The conflict between the neighbours has severely disrupted air travel in the region.

About a dozen Indian airports have shut down as of Wednesday evening. The nation's largest airline, IndiGo, announced the cancellation of 165 flights until Saturday morning.

Multiple carriers have been forced to adjust their operations. Korean Air has rerouted its Seoul Incheon-Dubai flights to a southern path over Myanmar, Bangladesh, and India.

Singapore Airlines ceased operations over Pakistani airspace since Tuesday, while Dutch airline KLM has suspended all flights over Pakistan until further notice. (Additional reporting by Reuters)