The Hang Seng Index fell 115 points, or 0.45 percent, to open at 25,714 on Tuesday.
Overnight, the three main indices in the US fell between 0.2 and 0.8 percent as the market awaited AI chip giant Nvidia's results mid-week.
On the mainland, the benchmark Shanghai Composite Index opened down 0.31 percent at 3,871, while the Shenzhen Component Index opened 0.34 percent lower at 12,398. (with additional reporting from Xinhua and AFP)