Chelsea slumped to another damaging home defeat against Brentford on Saturday as Eddie Nketiah hit a first Premier League hat-trick in a 5-0 win for Arsenal against struggling Sheffield United.

Mauricio Pochettino's Chelsea appeared to have turned a corner in recent weeks, taking seven points from their three previous fixtures, but their 2-0 loss means they have just one home win from their past 13 games in the league.

Ethan Pinnock took advantage of non-existent marking to head the visitors in front shortly before the hour mark at Stamford Bridge after Chelsea had failed to capitalise on their first-half dominance.

Goalkeeper Robert Sanchez was embarrassed in added time after joining his team's attack for a corner, failing to catch Neal Maupay in a race as he broke with the ball, allowing Bryan Mbeumo to score in an empty net to compound home fans' woes.

The result means Brentford leapfrog Chelsea into 10th place in the Premier League table, pushing Pochettino's men into the bottom half.

"I'm not happy and think the players also and the whole club is not happy about the run (at home)," said the Argentine manager.

It was a different story for London rivals Arsenal, who roared back from 2-0 down to draw against Chelsea last week to preserve their unbeaten league record.

Arsenal boss Mikel Arteta shuffled his pack – including dropping captain Martin Odegaard to the bench – for the visit of bottom club Sheffield United and Nketiah celebrated his recall to the starting line-up in style.

Replacing the injured Gabriel Jesus as Arsenal's target man at the Emirates Stadium, Nketiah proved he was up to the task as a swivelled finish gave the home side a 28th-minute lead.

The England forward arrowed a shot into the top corner early in the second half and completed his treble with a stunning strike from distance just before the hour mark.

Substitutes Fabio Vieira and Takehiro Tomiyasu added gloss to the scoreline with a penalty and a close-range finish as Arsenal moved up to second in the table, two points behind Tottenham, who beat Crystal Palace on Friday.

"For me, he is top level," said Arteta on Nketiah. "You look at the stats from his last 10 years, what he has done is remarkable."

Newcastle missed the chance to close in on the top four after twice letting the lead slip in a 2-2 draw at Wolves.

Bournemouth came from behind to beat fellow strugglers Burnley 2-1 and secure their first league win of the season thanks to a fine solo effort from Antoine Semenyo and a sensational lob from distance by Philip Billing late in the game.

Manchester City face Manchester United at Old Trafford in the pick of Sunday's action, while fourth-placed Liverpool host Nottingham Forest. (AFP)