Liverpool's Premier League title bid suffered a devastating blow in a 2-0 defeat at Merseyside rivals Everton, while Manchester United spared Erik ten Hag's blushes with a 4-2 victory against lowly Sheffield United on Wednesday.

Jurgen Klopp's side were beaten at Goodison Park for the first time in 14 years in a brutal setback to their hopes of catching leaders Arsenal.

Jarrad Branthwaite put Everton ahead in the 27th minute as the defender prodded the ball under Liverpool keeper Alisson Becker via the post after the Reds made a hash of clearing a free-kick.

With Liverpool's Mohamed Salah once again struggling to convert chances to equalise, Everton striker Dominic Calvert-Lewin delivered the knockout punch with a 58th-minute header.

Second-placed Liverpool remain three points behind Arsenal, who have a vastly superior goal difference, with both sides having four games left.

Liverpool have reportedly opened talks with Feyenoord's Arne Slot to take over from Klopp, whose long goodbye looks set to end with a whimper.

At Old Trafford, Ten Hag's side twice trailed to the league's bottom club before Bruno Fernandes came to his beleaguered manager's aid in the second half.

Jayden Bogle put the Blades ahead and although Harry Maguire equalised before half-time, Ben Brereton Diaz restored the visitors' advantage soon after the interval.

Fernandes bailed out Ten Hag with a penalty equaliser before the Portugal midfielder's long-range rocket put United in front with nine minutes left.

Rasmus Hojlund got United's fourth to ensure they could finally enjoy a first league win in five games since beating Everton on March 9.

Referee Stuart Attwell was embroiled in further controversy after contentiously disallowing a Wolves goal in Bournemouth's 1-0 win at Molineux.

Attwell was already in the spotlight for his role as VAR in denying Nottingham Forest three penalties in Sunday's 2-0 defeat at Everton, which led Forest to insinuate bias as he supports relegation rivals Luton.

This time, he adjudged Matheus Cunha to have fouled Justin Kluivert in an off-the-ball incident in the build up to Hwang Hee-chan's second-half equaliser, which looked to have cancelled out Antoine Semenyo's opener.

Jean-Philippe Mateta scored for a fifth consecutive home match to fire Crystal Palace to a 2-0 win over Newcastle. (AFP)