Hungary's Blanka Vas won the fifth stage of the Tour de France Femmes on Thursday with Dutch teammate Demi Vollering losing the race lead after being caught up in a big crash.

Poland's Katarzyna Niewiadoma finished second to take the leader's yellow jersey from defending champion Vollering who dropped to ninth overall.

A pile-up with six kilometres to go involving 10 riders including Vollering decimated the peloton in the run to Amneville in northeastern France.

The Team SD Worx leader now trails 1min 19sec behind her main rival Niewiadoma, who had started the stage 34 seconds behind Vollering. (AFP)