Australian cyclist Ben O'Connor soloed to a stunning victory in stage six of the Vuelta a España on Thursday, taking the red jersey from three-time winner Primoz Roglic.

The Decathlon AG2R La Mondiale rider and Gijs Leemreize attacked from a breakaway group before O'Connor later left the Dutchman behind with 27 kilometres to go.

O'Connor opened up a defendable lead of four minutes 51 seconds in the general classification ahead of veteran Roglic, as the peloton came in well over six minutes down.

"I felt a little bit in my own world today. I just went for it, I felt today was just a day to seize my opportunity and I laid it all out there," O'Connor said.

"I felt I could win this stage from the start – it's pretty special when you can just go out and crush it like that."

O'Connor became the fifth Australian to win stages at all three Grand Tours after winning at the Giro in 2020 and at the Tour de France in 2021. (AFP)